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What type of exposure can lead to poisoning from all fumigants?

  1. Prolonged moderate

  2. Single large

  3. Repeated small

  4. Environmental contamination

The correct answer is: Single large

The correct answer revolves around the concept of exposure intensity and its relationship with the potential for poisoning from fumigants. A single large exposure to a fumigant can overwhelm the body's ability to metabolize and eliminate the substance, leading to acute poisoning. This is particularly relevant because fumigants are designed to be toxic to pests, and when humans are exposed to a significant dose in one event, the effects can be severe and immediate. In contrast, prolonged moderate exposure may not reach the toxicity threshold that a single large exposure would, while repeated small exposures may allow the body to adapt or detoxify over time. Environmental contamination, while concerning, does not specifically designate the intensity or immediacy of exposure necessary for acute poisoning. Thus, if an individual encounters a significant, concentrated dose of a fumigant all at once, the risk of poisoning is greatly elevated, making this the best answer.